Mammalian Target of Rapamycin Cell Signaling Pathway Contributes to the Protective Effects of Ischemic Postconditioning Against Stroke | Zendy

Rong Xie | Zendy; Peng Wang | Zendy; Michelle Cheng | Zendy; Robert M. Sapolsky | Zendy; Xunming Ji | Zendy; Heng Zhao | Zendy

Open Access

Mammalian Target of Rapamycin Cell Signaling Pathway Contributes to the Protective Effects of Ischemic Postconditioning Against Stroke

Author(s) -

Rong Xie,

Peng Wang,

Michelle Cheng,

Robert M. Sapolsky,

Xunming Ji,

Heng Zhao

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.005406

Subject(s) - pi3k/akt/mtor pathway , p70 s6 kinase 1 , medicine , neuroprotection , in vivo , pharmacology , stroke (engine) , small hairpin rna , protein kinase b , signal transduction , apoptosis , gene knockdown , microbiology and biotechnology , biology , biochemistry , mechanical engineering , engineering

Whether the mammalian target of rapamycin (mTOR) pathway is protective against brain injury from stroke or is detrimental is controversial, and whether it is involved in the protective effects of ischemic postconditioning (IPC) against stroke is unreported. Our study focuses on the protective role of mTOR against neuronal injury after stroke with and without IPC.

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