Recognition Memory Impairments After Subcortical White Matter Stroke in Mice | Zendy

Francesco Blasi | Zendy; Ying Wei | Zendy; Mustafa Balkaya | Zendy; Saara Tikka | Zendy; Joseph B. Mandeville | Zendy; Christian Waeber | Zendy; Cenk Ayata | Zendy; Michael A. Moskowitz | Zendy

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Recognition Memory Impairments After Subcortical White Matter Stroke in Mice

Author(s) -

Francesco Blasi,

Ying Wei,

Mustafa Balkaya,

Saara Tikka,

Joseph B. Mandeville,

Christian Waeber,

Cenk Ayata,

Michael A. Moskowitz

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.005324

Subject(s) - medicine , white matter , lesion , corpus callosum , pathology , stroke (engine) , hyperintensity , neuroscience , anesthesia , magnetic resonance imaging , psychology , radiology , mechanical engineering , engineering

Small subcortical white matter infarcts are a common stroke subtype often associated with cognitive deficits. The lack of relevant models confined to white matter has limited the investigation of its pathophysiology. Here, we examine tissue and functional outcome after an ischemic lesion within corpus callosum in wild-type (WT) mice and in mice null for a gene, NOTCH3, linked to white matter ischemic injury in patients.

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