Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy | Zendy

Laibaik Park | Zendy; Kenzo Koizumi | Zendy; Sleiman El Jamal | Zendy; Ping Zhou | Zendy; Mary Lou Previti | Zendy; William E. Van Nostrand | Zendy; George A. Carlson | Zendy; Costantino Iadecola | Zendy

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Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

Author(s) -

Laibaik Park,

Kenzo Koizumi,

Sleiman El Jamal,

Ping Zhou,

Mary Lou Previti,

William E. Van Nostrand,

George A. Carlson,

Costantino Iadecola

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.005179

Subject(s) - cerebral amyloid angiopathy , medicine , neurovascular bundle , angiopathy , amyloid (mycology) , neuroscience , stroke (engine) , pathology , cardiology , dementia , endocrinology , disease , diabetes mellitus , mechanical engineering , engineering , biology

Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease. However, the functional correlates of the vascular pathology induced by cerebral amyloid angiopathy and the mechanisms involved have not been fully established.

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