Delayed Hyperbaric Oxygen Therapy Promotes Neurogenesis Through Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/β-Catenin Pathway in Middle Cerebral Artery Occlusion Rats | Zendy

Qin Hu | Zendy; Xiping Liang | Zendy; Di Chen | Zendy; Yujie Chen | Zendy; Desislava Doycheva | Zendy; Junjia Tang | Zendy; Jiping Tang | Zendy; John H. Zhang | Zendy

Open Access

Delayed Hyperbaric Oxygen Therapy Promotes Neurogenesis Through Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/β-Catenin Pathway in Middle Cerebral Artery Occlusion Rats

Author(s) -

Qin Hu,

Xiping Liang,

Di Chen,

Yujie Chen,

Desislava Doycheva,

Junjia Tang,

Jiping Tang,

John H. Zhang

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.005116

Subject(s) - neurogenesis , doublecortin , medicine , neuroprotection , synapsin i , anesthesia , reactive oxygen species , dentate gyrus , endocrinology , neuroscience , hippocampus , biology , microbiology and biotechnology , vesicle , genetics , membrane , synaptic vesicle

Hyperbaric oxygen (HBO) has been reported to be neuroprotective and to improve neurofunctional outcomes in acute stroke. However, it is not clear whether delayed HBO enhances endogenous neurogenesis and promotes neurofunctional recovery. The aim of this study is to evaluate the effects of delayed HBO therapy on neurogenesis and its potential mechanisms.

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