Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice
Author(s) -
Yaning Li,
Jun Huang,
Xiaosong He,
Guanghui Tang,
Yaohui Tang,
Yan Liu,
Xiaojie Lin,
Yifan Lu,
GuoYuan Yang,
Yongting Wang
Publication year - 2014
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.114.005078
Subject(s) - medicine , neurogenesis , progenitor cell , stromal cell , doublecortin , subventricular zone , neural stem cell , angiogenesis , cancer research , microbiology and biotechnology , stem cell , biology , hippocampus , dentate gyrus
Acute interventions of stroke are often challenged by a narrow treatment window. In this study, we explore treatments in the postacute phase of stroke with wider windows of opportunity. We investigated the effects of stromal cell-derived factor (SDF-1α) in neurovascular recovery during the postacute phase and downstream signaling pathways, underlying SDF-1α-mediated neurovascular recovery.
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