Dichotomous Effects of Chronic Intermittent Hypoxia on Focal Cerebral Ischemic Injury | Zendy

Katherine Jackman | Zendy; Ping Zhou | Zendy; Giuseppe Faraco | Zendy; Pablo M. Peixoto | Zendy; Christal G. Coleman | Zendy; Henning U. Voss | Zendy; Virginia M. Pickel | Zendy; Giovanni Manfredi | Zendy; Costantino Iadecola | Zendy

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Dichotomous Effects of Chronic Intermittent Hypoxia on Focal Cerebral Ischemic Injury

Author(s) -

Katherine Jackman,

Ping Zhou,

Giuseppe Faraco,

Pablo M. Peixoto,

Christal G. Coleman,

Henning U. Voss,

Virginia M. Pickel,

Giovanni Manfredi,

Costantino Iadecola

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.004816

Subject(s) - medicine , cerebral blood flow , hypoxia (environmental) , ischemia , anesthesia , neuroprotection , middle cerebral artery , cardiology , cerebral circulation , oxygen , chemistry , organic chemistry

Obstructive sleep apnea, a condition associated with chronic intermittent hypoxia (CIH), carries an increased risk of stroke. However, CIH has been reported to either increase or decrease brain injury in models of focal cerebral ischemia. The factors determining the differential effects of CIH on ischemic injury and their mechanisms remain unclear. Here, we tested the hypothesis that the intensity of the hypoxic challenge determines the protective or destructive nature of CIH by modulating mitochondrial resistance to injury.

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