17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status | Zendy

Poneh AdibSamii | Zendy; Natalia S. Rost | Zendy; Matthew Traylor | Zendy; William J. Devan | Zendy; Alessandro Biffi | Zendy; Silvia Lanfranconi | Zendy; Kaitlin Fitzpatrick | Zendy; Steve Bevan | Zendy; Allison Kanakis | Zendy; Valerie Valant | Zendy; Andreas Gschwendtner | Zendy; Rainer Malik | Zendy; Alexa Richie | Zendy; Dale M. Gamble | Zendy; Helen Segal | Zendy; Eugenio Parati | Zendy; Emilio Ciusani | Zendy; Elizabeth Holliday | Zendy; Jane Maguire | Zendy; Joanna M. Wardlaw | Zendy; Bradford B. Worrall | Zendy; Joshua C. Bis | Zendy; Kerri L. Wiggins | Zendy; W. T. Longstreth | Zendy; Steve J. Kittner | Zendy; Yu-Ching Cheng | Zendy; Thomas H. Mosley | Zendy; Guido J. Falcone | Zendy; Karen L. Furie | Zendy; Carlos LeivaSalinas | Zendy; Benison C. Lau | Zendy; Muhammed Saleem Khan | Zendy; Pankaj Sharma | Zendy; Myriam Fornage | Zendy; Braxton D. Mitchell | Zendy; Bruce M. Psaty | Zendy; Cathie Sudlow | Zendy; Christopher Levi | Zendy; Giorgio B. Boncoraglio | Zendy; Peter M. Rothwell | Zendy; James F. Meschia | Zendy; Martin Dichgans | Zendy; Jonathan Rosand | Zendy; Hugh S. Markus | Zendy

Open Access

17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status

Author(s) -

Poneh AdibSamii,

Natalia S. Rost,

Matthew Traylor,

William J. Devan,

Alessandro Biffi,

Silvia Lanfranconi,

Kaitlin Fitzpatrick,

Steve Bevan,

Allison Kanakis,

Valerie Valant,

Andreas Gschwendtner,

Rainer Malik,

Alexa Richie,

Dale M. Gamble,

Helen Segal,

Eugenio Parati,

Emilio Ciusani,

Elizabeth Holliday,

Jane Maguire,

Joanna M. Wardlaw,

Bradford B. Worrall,

Joshua C. Bis,

Kerri L. Wiggins,

W. T. Longstreth,

Steve J. Kittner,

Yu-Ching Cheng,

Thomas H. Mosley,

Guido J. Falcone,

Karen L. Furie,

Carlos LeivaSalinas,

Benison C. Lau,

Muhammed Saleem Khan,

Pankaj Sharma,

Myriam Fornage,

Braxton D. Mitchell,

Bruce M. Psaty,

Cathie Sudlow,

Christopher Levi,

Giorgio B. Boncoraglio,

Peter M. Rothwell,

James F. Meschia,

Martin Dichgans,

Jonathan Rosand,

Hugh S. Markus

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.679936

Subject(s) - lacunar stroke , medicine , stroke (engine) , hyperintensity , single nucleotide polymorphism , cardiology , ischemic stroke , physical therapy , magnetic resonance imaging , genetics , genotype , radiology , ischemia , gene , mechanical engineering , biology , engineering

Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate with lacunar stroke.

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