Role of SCH79797 in Maintaining Vascular Integrity in Rat Model of Subarachnoid Hemorrhage | Zendy

Junhao Yan | Zendy; Anatol Manaenko | Zendy; Sheng Chen | Zendy; Damon Klebe | Zendy; Qingyi Ma | Zendy; Başak Caner | Zendy; Mutsumi Fujii | Zendy; Changman Zhou | Zendy; John H. Zhang | Zendy

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Role of SCH79797 in Maintaining Vascular Integrity in Rat Model of Subarachnoid Hemorrhage

Author(s) -

Junhao Yan,

Anatol Manaenko,

Sheng Chen,

Damon Klebe,

Qingyi Ma,

Başak Caner,

Mutsumi Fujii,

Changman Zhou,

John H. Zhang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.678474

Subject(s) - medicine , evans blue , adherens junction , vascular permeability , subarachnoid hemorrhage , phosphorylation , thrombin , blood–brain barrier , microbiology and biotechnology , platelet , cadherin , biology , biochemistry , central nervous system , cell

Plasma thrombin concentration is increased after subarachnoid hemorrhage (SAH). However, the role of thrombin receptor (protease-activated receptor-1 [PAR-1]) in endothelial barrier disruption has not been studied. The aims of this study were to investigate the role of PAR-1 in orchestrating vascular permeability and to assess the potential therapeutics of a PAR-1 antagonist, SCH79797, through maintaining vascular integrity.

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