Nascent Proteomes in Peripheral Blood Mononuclear Cells as a Novel Source for Biomarker Discovery in Human Stroke | Zendy

Fang Bian | Zendy; Roger P. Simon | Zendy; Yun Li | Zendy; Larry L. David | Zendy; Jolita Wainwright | Zendy; Casey Hall | Zendy; Michael Frankel | Zendy; An Zhou | Zendy

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Nascent Proteomes in Peripheral Blood Mononuclear Cells as a Novel Source for Biomarker Discovery in Human Stroke

Author(s) -

Fang Bian,

Roger P. Simon,

Yun Li,

Larry L. David,

Jolita Wainwright,

Casey Hall,

Michael Frankel,

An Zhou

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.004576

Subject(s) - proteome , peripheral blood mononuclear cell , biomarker , proteomics , biomarker discovery , medicine , stroke (engine) , immunology , bioinformatics , biology , in vitro , biochemistry , gene , mechanical engineering , engineering

The proteome of newly synthesized proteins (nascent proteome) in peripheral blood mononuclear cells (PBMCs) can be a novel source of stroke biomarkers. Changes in the PBMC nascent proteome after stroke reflect the dynamic response-in-action not detectable in the total proteome (all existing proteins) in blood. Here, we test the application of nascent proteomics as a novel approach for stroke biomarker discovery.

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