Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice | Zendy

Wei Yang | Zendy; Huaxin Sheng | Zendy; J. Will Thompson | Zendy; Shengli Zhao | Zendy; Liangli Wang | Zendy; Pei Miao | Zendy; Xiaozhi Liu | Zendy; M. Arthur Moseley | Zendy; Wulf Paschen | Zendy

Open Access

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

Author(s) -

Wei Yang,

Huaxin Sheng,

J. Will Thompson,

Shengli Zhao,

Liangli Wang,

Pei Miao,

Xiaozhi Liu,

M. Arthur Moseley,

Wulf Paschen

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.004315

Subject(s) - sumo protein , ubiquitin , neuroprotection , transgene , proteome , genetically modified mouse , proteomics , biology , microbiology and biotechnology , biochemistry , pharmacology , gene

Small ubiquitin-like modifier (SUMO) conjugation is a post-translational modification associated with many human diseases. Characterization of the SUMO-modified proteome is pivotal to define the mechanistic link between SUMO conjugation and such diseases. This is particularly evident for SUMO2/3 conjugation, which is massively activated after brain ischemia/stroke, and is believed to be a protective response. The purpose of this study was to perform a comprehensive analysis of the SUMO3-modified proteome regulated by brain ischemia using a novel SUMO transgenic mouse.

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