Chelating Intracellularly Accumulated Zinc Decreased Ischemic Brain Injury Through Reducing Neuronal Apoptotic Death | Zendy

Yongmei Zhao | Zendy; Rong Pan | Zendy; Sen Li | Zendy; Yumin Luo | Zendy; Feng Yan | Zendy; Jie Yin | Zendy; Zhifeng Qi | Zendy; Ying Yan | Zendy; Xunming Ji | Zendy; Ke Jian Liu | Zendy

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Chelating Intracellularly Accumulated Zinc Decreased Ischemic Brain Injury Through Reducing Neuronal Apoptotic Death

Author(s) -

Yongmei Zhao,

Rong Pan,

Sen Li,

Yumin Luo,

Feng Yan,

Jie Yin,

Zhifeng Qi,

Ying Yan,

Xunming Ji,

Ke Jian Liu

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.004296

Subject(s) - medicine , ischemia , neuroprotection , pharmacology , intracellular , stroke (engine) , zinc , apoptosis , brain ischemia , reperfusion injury , anesthesia , endocrinology , biochemistry , biology , chemistry , mechanical engineering , organic chemistry , engineering

Zinc has been reported to possess both neurotoxic and neuroprotective capabilities. The effects of elevated intracellular zinc accumulation following transient focal cerebral ischemia remain to be fully elucidated. Here, we investigated whether removing zinc with the membrane-permeable zinc chelator, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), would decrease the intracellular levels of zinc in the ischemic tissue, leading to reduced brain damage and improved neurological outcomes.

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