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We appreciate the interest of Dr Tsuda in our recently published article.1 In our study, we showed that higher levels of alkaline phosphatase (ALP) were associated with a poor functional outcome after acute stroke, but phosphate was not. Dr Tsuda wanted to know whether the levels of ALP/phosphate were correlated with changes in bone mineral density (BMD) and serum vitamin D levels. Dr Tsuda’s questions were based on evidence that (1) there was an association between BMD and stroke; (2) lower serum 25-hydroxyvitamin D levels were associated with carotid atherosclerosis and fatal …

stroke

Response to Letter Regarding Article, “Serum Alkaline Phosphatase and Phosphate in Cerebral Atherosclerosis and Functional Outcomes After Cerebral Infarction”