White Matter Hyperintensities and Their Penumbra Lie Along a Continuum of Injury in the Aging Brain | Zendy

Pauline Maillard | Zendy; Evan Fletcher | Zendy; Samuel N. Lockhart | Zendy; Alexandra Roach | Zendy; Bruce Reed | Zendy; Dan Mungas | Zendy; Charles DeCarli | Zendy; Owen Carmichael | Zendy

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White Matter Hyperintensities and Their Penumbra Lie Along a Continuum of Injury in the Aging Brain

Author(s) -

Pauline Maillard,

Evan Fletcher,

Samuel N. Lockhart,

Alexandra Roach,

Bruce Reed,

Dan Mungas,

Charles DeCarli,

Owen Carmichael

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.004084

Subject(s) - medicine , hyperintensity , penumbra , white matter , stroke (engine) , magnetic resonance imaging , cardiology , radiology , ischemia , physics , thermodynamics

Aging is accompanied by clinically silent cerebral white matter injury identified through white matter hyperintensities (WMHs) on fluid-attenuated inversion recovery (FLAIR)- and diffusion tensor imaging-based measures of white matter integrity. The temporal course of FLAIR and diffusion tensor imaging changes within WMHs and their less-injured periphery (ie, their penumbra), however, has not been fully studied. We used longitudinal diffusion tensor imaging and FLAIR to explore these changes.

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