Effects of Tissue Plasminogen Activator and Annexin A2 Combination Therapy on Long-Term Neurological Outcomes of Rat Focal Embolic Stroke | Zendy

Xiaoshu Wang | Zendy; Xiang Fan | Zendy; Zhanyang Yu | Zendy; Zhengbu Liao | Zendy; Jianhua Zhao | Zendy; Emiri T. Mandeville | Zendy; Shuzhen Guo | Zendy; Eng H. Lo | Zendy; Xiaoying Wang | Zendy

Open Access

Effects of Tissue Plasminogen Activator and Annexin A2 Combination Therapy on Long-Term Neurological Outcomes of Rat Focal Embolic Stroke

Author(s) -

Xiaoshu Wang,

Xiang Fan,

Zhanyang Yu,

Zhengbu Liao,

Jianhua Zhao,

Emiri T. Mandeville,

Shuzhen Guo,

Eng H. Lo,

Xiaoying Wang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003823

Subject(s) - medicine , tissue plasminogen activator , plasminogen activator , stroke (engine) , penumbra , cerebral infarction , combination therapy , t plasminogen activator , ischemia , brain ischemia , neurovascular bundle , urology , pathology , mechanical engineering , engineering

Tissue-type plasminogen activator (tPA) in combination with recombinant annexin A2 (rA2) is known to reduce acute brain damage after focal ischemia. Here, we ask whether tPA-plus-rA2 combination therapy can lead to sustained long-term neurological improvements as well.

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