Peroxiredoxin 5 (PRX5) Is Correlated Inversely to Systemic Markers of Inflammation in Acute Stroke | Zendy

Allison Kunze | Zendy; Dannielle Zierath | Zendy; Patricia Tanzi | Zendy; Kevin C. Cain | Zendy; Kyra J. Becker | Zendy

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Peroxiredoxin 5 (PRX5) Is Correlated Inversely to Systemic Markers of Inflammation in Acute Stroke

Author(s) -

Allison Kunze,

Dannielle Zierath,

Patricia Tanzi,

Kevin C. Cain,

Kyra J. Becker

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003813

Subject(s) - medicine , inflammation , stroke (engine) , proinflammatory cytokine , systemic inflammation , peroxynitrite , immunology , mechanical engineering , biochemistry , chemistry , engineering , enzyme , superoxide

Peroxiredoxins are endogenous antioxidants that function as peroxide and peroxynitrite scavengers. Extracellular peroxiredoxins, however, are shown to initiate inflammation within the ischemic brain through activation of Toll-like receptors. Based on this observation, we hypothesized that plasma peroxiredoxin concentrations in ischemic stroke would correlate biomarkers of inflammation and predict poor outcome.

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