Allometric Dose Retranslation Unveiled Substantial Immunological Side Effects of Granulocyte Colony–Stimulating Factor After Stroke | Zendy

DanielChristoph Wagner | Zendy; Claudia Pösel | Zendy; Isabell Schulz | Zendy; Gerda Schicht | Zendy; Johannes Boltze | Zendy; Franziska Lange | Zendy; Johanna Scheibe | Zendy; Karoline Möller | Zendy; Gesa Weise | Zendy

Open Access

Allometric Dose Retranslation Unveiled Substantial Immunological Side Effects of Granulocyte Colony–Stimulating Factor After Stroke

Author(s) -

DanielChristoph Wagner,

Claudia Pösel,

Isabell Schulz,

Gerda Schicht,

Johannes Boltze,

Franziska Lange,

Johanna Scheibe,

Karoline Möller,

Gesa Weise

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003812

Subject(s) - medicine , stroke (engine) , spleen , granulocyte colony stimulating factor , neuroprotection , immune system , granulocyte , flow cytometry , immunology , pharmacology , chemotherapy , mechanical engineering , engineering

Granulocyte colony-stimulating factor (GCSF) showed robust neuroprotective and neuroregenerative properties after stroke in rodents but failed to meet study end points in patients. Because immunologic side effects of GCSF may have escaped preclinical testing because of nonallometric dose translation, we hypothesized those as possible reasons.

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