De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation | Zendy

Wanqiu Chen | Zendy; Zhengda Sun | Zendy; Zhenying Han | Zendy; Kristine Jun | Zendy; Marine Camus | Zendy; Mamta Wankhede | Zendy; Lei Mao | Zendy; Tom Arnold | Zendy; William L. Young | Zendy; Hua Su | Zendy

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De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation

Author(s) -

Wanqiu Chen,

Zhengda Sun,

Zhenying Han,

Kristine Jun,

Marine Camus,

Mamta Wankhede,

Lei Mao,

Tom Arnold,

William L. Young,

Hua Su

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003655

Subject(s) - pdgfb , angiogenesis , medicine , vascular endothelial growth factor , tamoxifen , pathology , stimulation , proliferation index , growth factor , cortical dysplasia , endocrinology , receptor , epilepsy , immunohistochemistry , platelet derived growth factor receptor , vegf receptors , cancer , breast cancer , psychiatry

In humans, activin receptor-like kinase 1 (Alk1) deficiency causes arteriovenous malformations (AVMs) in multiple organs, including the brain. Focal Alk1 pan-cellular deletion plus vascular endothelial growth factor stimulation induces brain AVMs in the adult mouse. We hypothesized that deletion of Alk1 in endothelial cell (EC) alone plus focal vascular endothelial growth factor stimulation is sufficient to induce brain AVM in the adult mouse.

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