Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke | Zendy

Kevin N. Sheth | Zendy; W. Taylor Kimberly | Zendy; Jordan Elm | Zendy; Thomas A. Kent | Zendy; Pitchaiah Mandava | Zendy; Albert J. Yoo | Zendy; Götz Thomalla | Zendy; Bruce Campbell | Zendy; Geoffrey A. Donnan | Zendy; Stephen M. Davis | Zendy; Gregory W. Albers | Zendy; Sven Jacobson | Zendy; J. Marc Simard | Zendy; Barney J. Stern | Zendy

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Pilot Study of Intravenous Glyburide in Patients With a Large Ischemic Stroke

Author(s) -

Kevin N. Sheth,

W. Taylor Kimberly,

Jordan Elm,

Thomas A. Kent,

Pitchaiah Mandava,

Albert J. Yoo,

Götz Thomalla,

Bruce Campbell,

Geoffrey A. Donnan,

Stephen M. Davis,

Gregory W. Albers,

Sven Jacobson,

J. Marc Simard,

Barney J. Stern

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003352

Subject(s) - medicine , modified rankin scale , stroke (engine) , tolerability , adverse effect , anesthesia , lesion , edema , target lesion , clinical trial , surgery , ischemia , ischemic stroke , percutaneous coronary intervention , mechanical engineering , myocardial infarction , engineering

Preclinical and retrospective clinical data indicate that glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing edema and improving outcome after focal ischemia. We assessed the feasibility of recruiting and treating patients with severe stroke while obtaining preliminary information on the safety and tolerability of RP-1127 (glyburide for injection).

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