Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats | Zendy

Yaoming Wang | Zendy; Zhen Zhao | Zendy; Nienwen Chow | Zendy; Padmesh S. Rajput | Zendy; John H. Griffin | Zendy; Patrick D. Lyden | Zendy; Berislav V. Zloković | Zendy

Open Access

Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats

Author(s) -

Yaoming Wang,

Zhen Zhao,

Nienwen Chow,

Padmesh S. Rajput,

John H. Griffin,

Patrick D. Lyden,

Berislav V. Zloković

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.003350

Subject(s) - medicine , therapeutic window , tissue plasminogen activator , plasminogen activator , stroke (engine) , t plasminogen activator , ischemic stroke , activator (genetics) , ischemia , fibrinolysis , endocrinology , pharmacology , receptor , mechanical engineering , engineering

3K3A-activated protein C (APC) protects young, healthy male rodents after ischemic stroke. 3K3A-APC is currently under development as a neuroprotectant for acute ischemic stroke in humans. Stroke Therapy Academic Industry Roundtable recommends that after initial studies in young, healthy male animals, further studies should be performed in females, aged animals, and animals with comorbid conditions. Here, we studied the effects of delayed 3KA-APC therapy alone and with tissue-type plasminogen activator (tPA) in aged female mice and spontaneously hypertensive rats.

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