Perfusion of Ischemic Brain in Young and Aged Animals | Zendy

Bharti Manwani | Zendy; Brett Friedler | Zendy; Rajkumar Verma | Zendy; Venugopal Reddy Venna | Zendy; Louise D. McCullough | Zendy; Fudong Liu | Zendy

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Perfusion of Ischemic Brain in Young and Aged Animals

Author(s) -

Bharti Manwani,

Brett Friedler,

Rajkumar Verma,

Venugopal Reddy Venna,

Louise D. McCullough,

Fudong Liu

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002944

Subject(s) - medicine , stroke (engine) , cerebral blood flow , perfusion , cd31 , blood–brain barrier , ischemia , pathology , middle cerebral artery , perfusion scanning , extravasation , microcirculation , cardiology , immunohistochemistry , central nervous system , mechanical engineering , engineering

Aging is an important determinant of ischemic stroke outcomes. Both clinical and experimental stroke studies have shown that aging negatively correlates with infarct volumes but is associated with worsened functional recovery after stroke. This may correspond to a differing cellular and molecular response to stroke in the aged versus young brain. It was hypothesized in this study that the smaller injury seen in the aged ischemic brain is because of structural differences in microvasculature with aging or differences in intraischemic tissue perfusion.

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