Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case–Control and Prospective Cohort Studies | Zendy

Rainer Malik | Zendy; Steve Bevan | Zendy; Michael A. Nalls | Zendy; Elizabeth G. Holliday | Zendy; William J. Devan | Zendy; Yu-Ching Cheng | Zendy; Carla A. IbrahimVerbaas | Zendy; Benjamin F.J. Verhaaren | Zendy; Joshua C. Bis | Zendy; Aron Y. Joon | Zendy; Anita L. de Stefano | Zendy; Myriam Fornage | Zendy; Bruce M. Psaty | Zendy; M. Arfan Ikram | Zendy; Lenore J. Launer | Zendy; Cornelia M. van Duijn | Zendy; Pankaj Sharma | Zendy; Braxton D. Mitchell | Zendy; Jonathan Rosand | Zendy; James F. Meschia | Zendy; Christopher Levi | Zendy; Peter M. Rothwell | Zendy; Cathie Sudlow | Zendy; Hugh S. Markus | Zendy; Sudha Seshadri | Zendy; Martin Dichgans | Zendy

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Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case–Control and Prospective Cohort Studies

Author(s) -

Rainer Malik,

Steve Bevan,

Michael A. Nalls,

Elizabeth G. Holliday,

William J. Devan,

Yu-Ching Cheng,

Carla A. IbrahimVerbaas,

Benjamin F.J. Verhaaren,

Joshua C. Bis,

Aron Y. Joon,

Anita L. de Stefano,

Myriam Fornage,

Bruce M. Psaty,

M. Arfan Ikram,

Lenore J. Launer,

Cornelia M. van Duijn,

Pankaj Sharma,

Braxton D. Mitchell,

Jonathan Rosand,

James F. Meschia,

Christopher Levi,

Peter M. Rothwell,

Cathie Sudlow,

Hugh S. Markus,

Sudha Seshadri,

Martin Dichgans

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002938

Subject(s) - medicine , prospective cohort study , epidemiology , population , stroke (engine) , case control study , genome wide association study , coronary artery disease , cohort study , cohort , genetic association , single nucleotide polymorphism , genotype , genetics , environmental health , mechanical engineering , biology , engineering , gene

Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts.

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