Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage | Zendy

Çiğdem Tosun | Zendy; David B. Kurland | Zendy; Rupal I. Mehta | Zendy; Rudy J. Castellani | Zendy; Joyce L. deJong | Zendy; Min Seong Kwon | Zendy; Seung Kyoon Woo | Zendy; Volodymyr Gerzanich | Zendy; J. Marc Simard | Zendy

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Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage

Author(s) -

Çiğdem Tosun,

David B. Kurland,

Rupal I. Mehta,

Rudy J. Castellani,

Joyce L. deJong,

Min Seong Kwon,

Seung Kyoon Woo,

Volodymyr Gerzanich,

J. Marc Simard

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002904

Subject(s) - neuroinflammation , medicine , glibenclamide , extravasation , entorhinal cortex , subarachnoid hemorrhage , downregulation and upregulation , neuroscience , anesthesia , pharmacology , pathology , endocrinology , inflammation , hippocampus , chemistry , biology , biochemistry , gene , diabetes mellitus

Subarachnoid hemorrhage (SAH) can leave patients with memory impairments that may not recover fully. Molecular mechanisms are poorly understood, and no treatment is available. The sulfonylurea receptor 1-transient receptor potential melastatin 4 (Sur1-Trpm4) channel plays an important role in acute central nervous system injury. We evaluated upregulation of Sur1-Trpm4 in humans with SAH and, in rat models of SAH, we examined Sur1-Trpm4 upregulation, its role in barrier dysfunction and neuroinflammation, and its consequences on spatial learning.

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