Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice | Zendy

Nobukazu Miyamoto | Zendy; Takakuni Maki | Zendy; LocDuyen D. Pham | Zendy; Kazuhide Hayakawa | Zendy; Ji Hae Seo | Zendy; Emiri T. Mandeville | Zendy; Joseph B. Mandeville | Zendy; KyuWon Kim | Zendy; Eng H. Lo | Zendy; Ken Arai | Zendy

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Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

Author(s) -

Nobukazu Miyamoto,

Takakuni Maki,

LocDuyen D. Pham,

Kazuhide Hayakawa,

Ji Hae Seo,

Emiri T. Mandeville,

Joseph B. Mandeville,

KyuWon Kim,

Eng H. Lo,

Ken Arai

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002813

Subject(s) - medicine , oxidative stress , white matter , cerebral hypoperfusion , perfusion , ischemia , stroke (engine) , anesthesia , neuroscience , magnetic resonance imaging , biology , radiology , mechanical engineering , engineering

White matter injury caused by cerebral hypoperfusion may contribute to the pathophysiology of vascular dementia and stroke, but the underlying mechanisms remain to be fully defined. Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair by disrupting renewal processes mediated by oligodendrocyte precursor cells (OPCs).

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