Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model | Zendy

Serge Marbacher | Zendy; Johan Marjamaa | Zendy; Katerina Bradacova | Zendy; Michael von Gunten | Zendy; Petri Honkanen | Zendy; Usama AboRamadan | Zendy; Juha Hernesniemi | Zendy; Mika Niemelä | Zendy; Juhana Frösén | Zendy

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Loss of Mural Cells Leads to Wall Degeneration, Aneurysm Growth, and Eventual Rupture in a Rat Aneurysm Model

Author(s) -

Serge Marbacher,

Johan Marjamaa,

Katerina Bradacova,

Michael von Gunten,

Petri Honkanen,

Usama AboRamadan,

Juha Hernesniemi,

Mika Niemelä,

Juhana Frösén

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002745

Subject(s) - aneurysm , medicine , thrombus , thrombosis , fibrosis , radiology , fusiform aneurysm , aorta , pathology , surgery

The biological mechanisms predisposing intracranial saccular aneurysms to growth and rupture are not yet fully understood. Mural cell loss is a histological hallmark of ruptured cerebral aneurysms. It remains unclear whether mural cell loss predisposes to aneurysm growth and eventual rupture.

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