Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease
Author(s) -
Martin Dichgans,
Rainer Malik,
Inke R. König,
Jonathan Rosand,
Robert Clarke,
Sólveig Grétarsdóttir,
Guðmar Þorleifsson,
Braxton D. Mitchell,
Themistocles L. Assimes,
Christopher Levi,
Christopher J O Donnell,
Myriam Fornage,
Unnur Þorsteinsdóttir,
Bruce M. Psaty,
Christian Hengstenberg,
Sudha Seshadri,
Jeanette Erdmann,
Joshua C. Bis,
Annette Peters,
Giorgio B. Boncoraglio,
Winfried März,
James F. Meschia,
Sekar Kathiresan,
M. Arfan Ikram,
Ruth McPherson,
Kári Stéfansson,
Cathie Sudlow,
Muredach P. Reilly,
J. Thompson,
Pankaj Sharma,
Jemma C. Hopewell,
John C. Chambers,
Hugh Watkins,
Peter M. Rothwell,
Robert J. Roberts,
Hugh S. Markus,
Nilesh J. Samani,
Martin Farrall,
Heribert Schunkert,
Andreas Gschwendtner,
Steve Bevan,
YuChing Chen,
Anita L. DeStefano,
Eugenio Parati,
Thomas Quertermous,
Andreas Ziegler,
Eric Boerwinkle,
Hilma Hólm,
Marcus Fischer,
Thorsten Kessler,
Christina Willenborg,
Reijo Laaksonen,
Benjamin F. Voight,
Alexandre F.R. Stewart,
Daniel J. Rader,
Alistair S. Hall,
Jaspal S. Kooner
Publication year - 2013
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.113.002707
Subject(s) - genome wide association study , coronary artery disease , medicine , heritability , genetic association , genetics , disease , stroke (engine) , clinical significance , cardiology , bioinformatics , single nucleotide polymorphism , biology , genotype , gene , mechanical engineering , engineering
Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases.
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