Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery | Zendy

Joseph P. Mathew | Zendy; William D. White | Zendy; David B. Schinderle | Zendy; Mihai V. Podgoreanu | Zendy; Miles Berger | Zendy; Carmelo A. Milano | Zendy; Daniel T. Laskowitz | Zendy; Mark StaffordSmith | Zendy; James A. Blumenthal | Zendy; Mark F. Newman | Zendy; Manuel A. Fontes | Zendy; Miklós D. Kertai | Zendy; Frederick W. Lombard | Zendy; David L. McDonagh | Zendy; Terri G. Monk | Zendy; Madhav Swaminathan | Zendy; David S. Warner | Zendy; Bonita L. Funk | Zendy; Narai Balajonda | Zendy; Roger L. Hall | Zendy; Tiffany Bisanar | Zendy; Karen Clemmons | Zendy; YiJu Li | Zendy; Greg Pecora | Zendy; Yanne Toulgoat-Dubois | Zendy; Peter Waweru | Zendy; Michael A. Babyak | Zendy; Jeffrey N. Browndyke | Zendy; Kathleen A. WelshBohmer | Zendy; Daniel B. Mark | Zendy; Michael H. Sketch | Zendy; Ellen Bennett | Zendy; Carmelo Graffagnino | Zendy; Warren J. Strittmatter | Zendy; Stanlin Alexander | Zendy; Kevin Collins | Zendy; Greg Smigla | Zendy; Ian Shearer | Zendy; Mark F. Berry | Zendy; Thomas A. D’Amico | Zendy; Mani A. Daneshmand | Zendy; R. Duane Davis | Zendy; Jeffrey G. Gaca | Zendy; Donald D. Glower | Zendy; R. David Harpole | Zendy; G. Chad Hughes | Zendy; Robert D.B. Jaquiss | Zendy; Shu S. Lin | Zendy; Andrew J. Lodge | Zendy; Mark W. Onaitis | Zendy; J. Schroeder | Zendy; Peter K. Smith | Zendy; Betty C. Tong | Zendy

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Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery

Author(s) -

Joseph P. Mathew,

William D. White,

David B. Schinderle,

Mihai V. Podgoreanu,

Miles Berger,

Carmelo A. Milano,

Daniel T. Laskowitz,

Mark StaffordSmith,

James A. Blumenthal,

Mark F. Newman,

Manuel A. Fontes,

Miklós D. Kertai,

Frederick W. Lombard,

David L. McDonagh,

Terri G. Monk,

Madhav Swaminathan,

David S. Warner,

Bonita L. Funk,

Narai Balajonda,

Roger L. Hall,

Tiffany Bisanar,

Karen Clemmons,

YiJu Li,

Greg Pecora,

Yanne Toulgoat-Dubois,

Peter Waweru,

Michael A. Babyak,

Jeffrey N. Browndyke,

Kathleen A. WelshBohmer,

Daniel B. Mark,

Michael H. Sketch,

Ellen Bennett,

Carmelo Graffagnino,

Warren J. Strittmatter,

Stanlin Alexander,

Kevin Collins,

Greg Smigla,

Ian Shearer,

Mark F. Berry,

Thomas A. D’Amico,

Mani A. Daneshmand,

R. Duane Davis,

Jeffrey G. Gaca,

Donald D. Glower,

R. David Harpole,

G. Chad Hughes,

Robert D.B. Jaquiss,

Shu S. Lin,

Andrew J. Lodge,

Mark W. Onaitis,

J. Schroeder,

Peter K. Smith,

Betty C. Tong

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002703

Subject(s) - medicine , placebo , anesthesia , bolus (digestion) , platelet activation , randomized controlled trial , surgery , platelet , pathology , alternative medicine

Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl-D-aspartate receptor, diminution of the inflammatory response, and inhibition of platelet activation. We therefore hypothesized that intraoperative magnesium administration would decrease postoperative cognitive impairment.

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