Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia | Zendy

Peiying Li | Zendy; Leilei Mao | Zendy; Guoqing Zhou | Zendy; Rehana K. Leak | Zendy; Baoliang Sun | Zendy; Jun Chen | Zendy; Xiaoming Hu | Zendy

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Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia

Author(s) -

Peiying Li,

Leilei Mao,

Guoqing Zhou,

Rehana K. Leak,

Baoliang Sun,

Jun Chen,

Xiaoming Hu

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002637

Subject(s) - medicine , immunosuppression , immune system , ischemia , regulatory t cell , immunology , il 2 receptor , foxp3 , spleen , t cell

Cerebral ischemia has been shown to result in peripheral inflammatory responses followed by long-lasting immunosuppression. Our recent study demonstrated that intravenous delivery of regulatory T cells (Tregs) markedly protected against transient cerebral ischemia by suppressing neutrophil-derived matrix metallopeptidase 9 production in the periphery. However, the effect of Tregs on systemic inflammatory responses and immune status has not been fully characterized.

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