Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke | Zendy

Zhenjun Tan | Zendy; Ryan C. Turner | Zendy; Rachel L. León | Zendy; Xinlan Li | Zendy; Jarin Hongpaisan | Zendy; Wen Zheng | Zendy; Aric F. Logsdon | Zendy; Zachary J. Naser | Zendy; Daniel L. Alkon | Zendy; Charles L. Rosen | Zendy; Jason D. Huber | Zendy

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Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke

Author(s) -

Zhenjun Tan,

Ryan C. Turner,

Rachel L. León,

Xinlan Li,

Jarin Hongpaisan,

Wen Zheng,

Aric F. Logsdon,

Zachary J. Naser,

Daniel L. Alkon,

Charles L. Rosen,

Jason D. Huber

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002411

Subject(s) - medicine , bryostatin 1 , ischemia , astrogliosis , tissue plasminogen activator , lesion , anesthesia , stroke (engine) , surgery , central nervous system , activator (genetics) , mechanical engineering , receptor , engineering

Bryostatin, a potent protein kinase C (PKC) activator, has demonstrated therapeutic efficacy in preclinical models of associative memory, Alzheimer disease, global ischemia, and traumatic brain injury. In this study, we tested the hypothesis that administration of bryostatin provides a therapeutic benefit in reducing brain injury and improving stroke outcome using a clinically relevant model of cerebral ischemia with tissue plasminogen activator reperfusion in aged rats.

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