Response to Letter by Siegler and Martin-Schild Regarding Article, “Comparison of Risk-Scoring Systems in Predicting Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis”

We thank Drs Siegler and Martin-Schild for their comments on our study comparing various risk-scoring systems in predicting symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis in a Taiwanese population.1 They correctly pointed out that potential patient selection bias could impact the performance of the discussed scoring models. They are also concerned that clinical application of the risk scores might unnecessarily discourage the use of thrombolysis, of which the current sICH rate is reasonably low.Indeed, generalizability of prediction models depends on the quality of the model as developed …