Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size | Zendy

Qian Li | Zendy; Dmitriy N. Atochin | Zendy; Satoshi Kashiwagi | Zendy; J. A. P. Earle | Zendy; Annie Wang | Zendy; Emiri T. Mandeville | Zendy; Kazuhide Hayakawa | Zendy; Livius V. d’Uscio | Zendy; Eng H. Lo | Zendy; Zvonimir S. Katušić | Zendy; William C. Sessa | Zendy; Paul L. Huang | Zendy

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Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size

Author(s) -

Qian Li,

Dmitriy N. Atochin,

Satoshi Kashiwagi,

J. A. P. Earle,

Annie Wang,

Emiri T. Mandeville,

Kazuhide Hayakawa,

Livius V. d’Uscio,

Eng H. Lo,

Zvonimir S. Katušić,

William C. Sessa,

Paul L. Huang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.002073

Subject(s) - enos , medicine , endocrinology , phosphorylation , stroke (engine) , diabetes mellitus , serine , endothelial dysfunction , middle cerebral artery , cardiology , ischemia , biology , nitric oxide , nitric oxide synthase , biochemistry , mechanical engineering , engineering

Phosphorylation of eNOS, an important post-translational modulator of its enzymatic activity, is reduced in diabetes mellitus. We hypothesized that modulation of eNOS phosphorylation could overcome diabetic vascular dysfunction and improves the outcome to stroke.

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