Open AccessIsoflurane Post-Treatment Ameliorates GMH-Induced Brain Injury in Neonatal Rats
Author(s) -
Arthur Leitzke,
William Rolland,
Paul R. Krafft,
Tim Lekic,
Damon Klebe,
Jerry Flores,
Nicole R. Van Allen,
Richard L. Applegate,
John H. Zhang
Publication year - 2013
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.113.001988
Subject(s) - isoflurane , medicine , sphingosine , protein kinase b , pharmacology , antagonist , anesthesia , sphingosine 1 phosphate , sphingosine kinase , endocrinology , receptor , phosphorylation , biochemistry , biology
This study investigated whether isoflurane ameliorates neurological sequelae after germinal matrix hemorrhage (GMH) through activation of the cytoprotective sphingosine kinase/sphingosine-1-phosphate receptor/Akt pathway.
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