Age-Dependent Exacerbation of White Matter Stroke Outcomes | Zendy

Shira Rosenzweig | Zendy; S. Thomas Carmichael | Zendy

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Age-Dependent Exacerbation of White Matter Stroke Outcomes

Author(s) -

Shira Rosenzweig,

S. Thomas Carmichael

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001796

Subject(s) - medicine , white matter , stroke (engine) , atrophy , neuroinflammation , oligodendrocyte , stroke recovery , forelimb , motor cortex , pathology , neuroscience , inflammation , anesthesia , central nervous system , anatomy , psychology , rehabilitation , physical therapy , myelin , magnetic resonance imaging , mechanical engineering , engineering , radiology , stimulation

Subcortical white matter stroke (WMS) constitutes up to 30% of all stroke subtypes. Mechanisms of oligodendrocyte and axon injury and repair play a central role in the damage and recovery after this type of stroke, and a comprehensive study of these processes requires a specialized experimental model that is different from common large artery, gray matter stroke models. Diminished recovery from stroke in aged patients implies that damage and repair processes are affected by advanced age, but such effects have not been studied in WMS.

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