Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage | Zendy

Macarena HernándezJiménez | Zendy; Olivia Hurtado | Zendy; María Isabel Cuartero | Zendy; Iván Ballesteros | Zendy; Ana Moraga | Zendy; Jesús M. Pradillo | Zendy; Michael W. McBurney | Zendy; Ignacio Lizasoaín | Zendy; Marı́a A. Moro | Zendy

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Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

Author(s) -

Macarena HernándezJiménez,

Olivia Hurtado,

María Isabel Cuartero,

Iván Ballesteros,

Ana Moraga,

Jesús M. Pradillo,

Michael W. McBurney,

Ignacio Lizasoaín,

Marı́a A. Moro

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001715

Subject(s) - medicine , regulator , ischemic stroke , stroke (engine) , ischemia , neuroscience , mechanical engineering , biochemistry , biology , engineering , gene , chemistry

Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein deacetylases implicated in a wide range of cellular functions and has beneficial properties in pathologies including ischemia/reperfusion processes and neurodegeneration. However, no direct evidence has been reported on the direct implication of SIRT1 in ischemic stroke. The aim of this study was to establish the role of SIRT1 in stroke using an experimental model in mice.

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