Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice | Zendy

Nobukazu Miyamoto | Zendy; LocDuyen D. Pham | Zendy; Kazuhide Hayakawa | Zendy; Toshinori Matsuzaki | Zendy; Ji Hae Seo | Zendy; Caroline Magnain | Zendy; Cenk Ayata | Zendy; KyuWon Kim | Zendy; David A. Boas | Zendy; Eng H. Lo | Zendy; Ken Arai | Zendy

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Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice

Author(s) -

Nobukazu Miyamoto,

LocDuyen D. Pham,

Kazuhide Hayakawa,

Toshinori Matsuzaki,

Ji Hae Seo,

Caroline Magnain,

Cenk Ayata,

KyuWon Kim,

David A. Boas,

Eng H. Lo,

Ken Arai

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001530

Subject(s) - oligodendrocyte , white matter , medicine , endocrinology , corpus callosum , myelin , endogeny , myelin basic protein , neuroscience , anesthesia , central nervous system , pathology , biology , magnetic resonance imaging , radiology

Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms of injury/repair in white matter remain to be fully elucidated. Here, we ask whether, compared with young brains, white matter regions in older brains may be more vulnerable in part because of decreased rates of compensatory oligodendrogenesis after injury.

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