Lipoprotein Receptor–Related Protein-6 Protects the Brain From Ischemic Injury | Zendy

T Abe | Zendy; Ping Zhou | Zendy; Katherine Jackman | Zendy; Carmen Capone | Zendy; Barbara Casolla | Zendy; Karin Hochrainer | Zendy; Timo Kahles | Zendy; M. Elizabeth Ross | Zendy; Josef Anrather | Zendy; Costantino Iadecola | Zendy

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Lipoprotein Receptor–Related Protein-6 Protects the Brain From Ischemic Injury

Author(s) -

T Abe,

Ping Zhou,

Katherine Jackman,

Carmen Capone,

Barbara Casolla,

Karin Hochrainer,

Timo Kahles,

M. Elizabeth Ross,

Josef Anrather,

Costantino Iadecola

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001320

Subject(s) - medicine , gsk 3 , proinflammatory cytokine , neuroprotection , mitochondrion , ischemia , endocrinology , pharmacology , phosphorylation , microbiology and biotechnology , biology , inflammation

Loss-of-function mutations of the lipoprotein receptor-related protein-6 (LRP6), a coreceptor in the Wingless-related integration site-β-catenin prosurvival pathway, have been implicated in myocardial ischemia and neurodegeneration. However, it remains to be established whether LRP6 is also involved in ischemic brain injury. We used LRP6+/- mice to examine the role of this receptor in the mechanisms of focal cerebral ischemia.

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