Open AccessLetter by Cappellari et al Regarding Article, “Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-analysis of Observational Studies and Randomized Trials”
Author(s) -
Manuel Cappellari,
Giuseppe Moretto,
Paolo Bovi
Publication year - 2013
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.113.001207
Subject(s) - medicine , observational study , stroke (engine) , randomized controlled trial , odds ratio , modified rankin scale , thrombolysis , confidence interval , meta analysis , physical therapy , surgery , ischemic stroke , ischemia , myocardial infarction , mechanical engineering , engineering
In recent contribution of Stroke , Ni Chroinin et al1 reported that in patients treated with intravenous thrombolysis, statin treatment at stroke onset was not associated with favorable functional outcome (modified Rankin Scale, ≤2) at 90 days (odds ratio [OR], 1.01; 95% confidence interval [CI], 0.88–1.15; P =0.93, data available from 5 observational studies, 4993 patients). Also, it was associated with an increased fatality at 90 days (pooled OR, 1.25; 95% CI, 1.02–1.52; P =0.03, 3 observational studies, 4339 patients), although this association was not observed after adjustment for potential confounding variables.The main point concerns the eligibility to intravenous thrombolysis for patients under statin treatment at stroke onset. The following 2 observations are given to illustrate …
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