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Recent pharmacological evidence shows that antagonists for the metabotropic glutamate 1 (mGlu1) receptor exhibit neuroprotective effects in an ischemic brain. The aim of this study was to visualize the mGlu1 receptor and to monitor neuroprotective effects in a rat model of mild focal ischemia using positron emission tomography (PET) with N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-[(11)C]methoxy-N-methylbenzamide ([(11)C]ITMM), a radiotracer for mGlu1.

Monitoring Neuroprotective Effects Using Positron Emission Tomography With [ 11 C]ITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor

Monitoring Neuroprotective Effects Using Positron Emission Tomography With [ ¹¹ C]ITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor