Monitoring Neuroprotective Effects Using Positron Emission Tomography With [ 11 C]ITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor | Zendy

Joji Yui | Zendy; Lin Xie | Zendy; Masayuki Fujinaga | Zendy; Tomoteru Yamasaki | Zendy; Akiko Hatori | Zendy; Katsushi Kumata | Zendy; Nobuki Nengaki | Zendy; MingRong Zhang | Zendy

Open Access

Monitoring Neuroprotective Effects Using Positron Emission Tomography With [ ¹¹ C]ITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor

Author(s) -

Joji Yui,

Lin Xie,

Masayuki Fujinaga,

Tomoteru Yamasaki,

Akiko Hatori,

Katsushi Kumata,

Nobuki Nengaki,

MingRong Zhang

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001178

Subject(s) - neuroprotection , medicine , metabotropic receptor , glutamate receptor , positron emission tomography , metabotropic glutamate receptor , minocycline , pharmacology , in vivo , metabotropic glutamate receptor 5 , nuclear medicine , anesthesia , receptor , biochemistry , chemistry , biology , microbiology and biotechnology , antibiotics

Recent pharmacological evidence shows that antagonists for the metabotropic glutamate 1 (mGlu1) receptor exhibit neuroprotective effects in an ischemic brain. The aim of this study was to visualize the mGlu1 receptor and to monitor neuroprotective effects in a rat model of mild focal ischemia using positron emission tomography (PET) with N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-[(11)C]methoxy-N-methylbenzamide ([(11)C]ITMM), a radiotracer for mGlu1.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research