Explicit Consideration of Baseline Factors to Assess Recombinant Tissue-Type Plasminogen Activator Response With Respect to Race and Sex | Zendy

Pitchaiah Mandava | Zendy; Santosh B. Murthy | Zendy; Melody Munoz | Zendy; Dawn McGuire | Zendy; Roger P. Simon | Zendy; Andrei V. Alexandrov | Zendy; Karen C. Albright | Zendy; Amelia K. Boehme | Zendy; Sheryl MartinSchild | Zendy; Sharyl Martini | Zendy; Thomas A. Kent | Zendy

Open Access

Explicit Consideration of Baseline Factors to Assess Recombinant Tissue-Type Plasminogen Activator Response With Respect to Race and Sex

Author(s) -

Pitchaiah Mandava,

Santosh B. Murthy,

Melody Munoz,

Dawn McGuire,

Roger P. Simon,

Andrei V. Alexandrov,

Karen C. Albright,

Amelia K. Boehme,

Sheryl MartinSchild,

Sharyl Martini,

Thomas A. Kent

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.001116

Subject(s) - medicine , plasminogen activator , recombinant dna , race (biology) , baseline (sea) , cardiology , surgery , genetics , botany , biology , oceanography , gene , geology

Sex and race reportedly influence outcome after recombinant tissue-type plasminogen activator (rtPA). It is, however, unclear whether baseline imbalances (eg, stroke severity) or lack of response to thrombolysis is responsible. We applied balancing methods to test the hypothesis that race and sex influence outcome after rtPA independent of baseline conditions.

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