Spatiotemporal Uptake Characteristics of [ 18 ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model | Zendy

Hong Yuan | Zendy; Jonathan E. Frank | Zendy; Yonglong Hong | Zendy; Hongyu An | Zendy; Cihat Eldeniz | Zendy; Jingxin Nie | Zendy; Adomas Bunevičius | Zendy; Dinggang Shen | Zendy; Weili Lin | Zendy

Open Access

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Author(s) -

Hong Yuan,

Jonathan E. Frank,

Yonglong Hong,

Hongyu An,

Cihat Eldeniz,

Jingxin Nie,

Adomas Bunevičius,

Dinggang Shen,

Weili Lin

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.113.000903

Subject(s) - medicine , cerebral blood flow , middle cerebral artery , ischemia , positron emission tomography , occlusion , cerebral infarction , nuclear medicine , blood flow , effective diffusion coefficient , glucose uptake , infarction , magnetic resonance imaging , radiology , insulin , myocardial infarction

Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome.

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