Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions | Zendy

Marius de Groot | Zendy; Benjamin F.J. Verhaaren | Zendy; Renske de Boer | Zendy; Stefan Klein | Zendy; Albert Hofman | Zendy; Aad van der Lugt | Zendy; M. Arfan Ikram | Zendy; Wiro J. Niessen | Zendy; Meike W. Vernooij | Zendy

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Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions

Author(s) -

Marius de Groot,

Benjamin F.J. Verhaaren,

Renske de Boer,

Stefan Klein,

Albert Hofman,

Aad van der Lugt,

M. Arfan Ikram,

Wiro J. Niessen,

Meike W. Vernooij

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.680223

Subject(s) - fractional anisotropy , white matter , fluid attenuated inversion recovery , medicine , diffusion mri , nuclear medicine , hyperintensity , voxel , population , magnetic resonance imaging , nuclear magnetic resonance , radiology , physics , environmental health

It is unknown whether white matter lesions (WML) develop abruptly in previously normal brain areas, or whether tissue changes are already present before WML become apparent on MRI. We therefore investigated whether development of WML is preceded by quantifiable changes in normal-appearing white matter (NAWM).

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