Open AccessThe Neurorestorative Benefit of GW3965 Treatment of Stroke in Mice
Author(s) -
Xu Cui,
Michael Chopp,
Alex Zacharek,
Yisheng Cui,
Cynthia J. Roberts,
Jieli Chen
Publication year - 2012
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.112.677682
Subject(s) - medicine , arteriogenesis , stroke (engine) , middle cerebral artery , endocrinology , angiogenesis , ischemia , mechanical engineering , engineering
GW3965, a synthetic liver X receptor agonist, elevates high-density lipoprotein cholesterol and has antiatherosclerosis and anti-inflammation properties. We tested the hypothesis that GW3965 treatment of stroke increases vascular remodeling, promotes synaptic protein expression and axonal growth in the ischemic brain, and improves functional outcome in mice.
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