Medial Premotor Cortex Shows a Reduction in Inhibitory Markers and Mediates Recovery in a Mouse Model of Focal Stroke | Zendy

Steven R. Zeiler | Zendy; Ellen Gibson | Zendy; Robert Hoesch | Zendy; Mingyong Li | Zendy; Paul F. Worley | Zendy; Richard O’Brien | Zendy; John W. Krakauer | Zendy

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Medial Premotor Cortex Shows a Reduction in Inhibitory Markers and Mediates Recovery in a Mouse Model of Focal Stroke

Author(s) -

Steven R. Zeiler,

Ellen Gibson,

Robert Hoesch,

Mingyong Li,

Paul F. Worley,

Richard O’Brien,

John W. Krakauer

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.676940

Subject(s) - forelimb , premotor cortex , neuroscience , motor cortex , stroke (engine) , inhibitory postsynaptic potential , lesion , medicine , cortex (anatomy) , primary motor cortex , neuroplasticity , calretinin , parvalbumin , neocortex , supplementary motor area , anatomy , psychology , pathology , functional magnetic resonance imaging , immunohistochemistry , stimulation , mechanical engineering , dorsum , engineering

Motor recovery after ischemic stroke in primary motor cortex is thought to occur in part through training-enhanced reorganization in undamaged premotor areas, enabled by reductions in cortical inhibition. Here we used a mouse model of focal cortical stroke and a double-lesion approach to test the idea that a medial premotor area (medial agranular cortex [AGm]) reorganizes to mediate recovery of prehension, and that this reorganization is associated with a reduction in inhibitory interneuron markers.

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