Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1 | Zendy

Juliane Schulze | Zendy; Dannielle Zierath | Zendy; Patricia Tanzi | Zendy; Kevin C. Cain | Zendy; Dean Shibata | Zendy; Alexander Dressel | Zendy; Kyra J. Becker | Zendy

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Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1

Author(s) -

Juliane Schulze,

Dannielle Zierath,

Patricia Tanzi,

Kevin C. Cain,

Dean Shibata,

Alexander Dressel,

Kyra J. Becker

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.676072

Subject(s) - medicine , stroke (engine) , ischemic stroke , cardiology , ischemia , mechanical engineering , engineering

The signals that initiate the poststroke inflammatory response are unknown. High-mobility group box (HMGB) 1 protein is a nuclear protein that is passively released from necrotic tissue and is able to activate leukocytes, which in turn secrete HMGB1. HMGB1 is also able to activate antigen-presenting cells and therefore stands at the crossroads of innate and adaptive immunity.

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