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To the Editor:We read with great interest the article by Marielle et al1 that was recently published in Stroke . In their population-based study that included 1460 participants, increased arterial stiffness indicated by aortic pulse wave velocity (PWV), a conventional measurement of arterial stiffness, was associated with a larger volume of white matter lesions. Furthermore, lacunar infarcts and deep or infratentorial microbleeds were associated with a higher aortic PWV in persons with uncontrolled hypertension.We applaud their results, because we also showed an independent association between cerebral small vessel disease and increased arterial stiffness indicated by brachial-ankle …

Letter by Saji and Kimura Regarding Article, “Arterial Stiffness and Cerebral Small Vessel Disease: The Rotterdam Scan Study”