Immediate Hypothermia Is Not Neuroprotective After Severe Hypoxia-Ischemia and Is Deleterious When Delayed by 12 Hours in Neonatal Rats | Zendy

Hemmen Sabir | Zendy; Emma Scull-Brown | Zendy; Xun Liu | Zendy; Marianne Thoresen | Zendy

Open Access

Immediate Hypothermia Is Not Neuroprotective After Severe Hypoxia-Ischemia and Is Deleterious When Delayed by 12 Hours in Neonatal Rats

Author(s) -

Hemmen Sabir,

Emma Scull-Brown,

Xun Liu,

Marianne Thoresen

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.674481

Subject(s) - medicine , neuroprotection , hypothermia , hypoxia (environmental) , ischemia , anesthesia , stroke (engine) , cardiology , oxygen , mechanical engineering , engineering , chemistry , organic chemistry

Hypothermia (HT) for neonatal hypoxic-ischemic encephalopathy is advised to start within the first 6 hours after birth. There is some clinical evidence that HT is more effective against moderate than against severe hypoxic-ischemic encephalopathy, but it is unknown whether delayed HT beyond 6 hours is effective or even injurious.

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