Intraventricular Fibrinolysis Does Not Increase Perihemorrhagic Edema After Intracerebral Hemorrhage | Zendy

Bastian Volbers | Zendy; Ingrid Wagner | Zendy; Wolfgang Willfarth | Zendy; Arnd Doerfler | Zendy; Stefan Schwab | Zendy; Dimitre Staykov | Zendy

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Intraventricular Fibrinolysis Does Not Increase Perihemorrhagic Edema After Intracerebral Hemorrhage

Author(s) -

Bastian Volbers,

Ingrid Wagner,

Wolfgang Willfarth,

Arnd Doerfler,

Stefan Schwab,

Dimitre Staykov

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.673228

Subject(s) - medicine , fibrinolysis , intracerebral hemorrhage , intraventricular hemorrhage , brain edema , edema , anesthesia , stroke (engine) , cerebral edema , cardiology , subarachnoid hemorrhage , pregnancy , biology , genetics , gestational age , mechanical engineering , engineering

Additional intraventricular hemorrhage leads to higher mortality and worse functional outcome after intracerebral hemorrhage (ICH). Intraventricular fibrinolysis (IVF) with recombinant tissue plasminogen activator (rtPA) is an emerging treatment strategy for such patients. However, experimental studies suggest that rtPA may exert proedematous effects and lead to increased perihemorrhagic edema (PHE) after ICH. We aimed to compare the course of PHE after ICH between patients who received IVF with rtPA and controls matched for ICH volume.

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