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We read with interest the article on diagnosis of subarachnoid hemorrhage (SAH) by early CT scans that proposes to eliminate the need for cerebrospinal fluid absorption spectrophotometry analysis.1 Although we have an almost similar experience with early CT imaging with the modern multislice scanners, the numeric value of 100% for all the accuracy parameters needs to be interpreted carefully, especially in view of the relatively small cohort size of 137 patients.The message that there is no added value of cerebrospinal fluid analysis if CT scan of the head, performed within 6 hours, is normal in patients with acute headache might be applicable only to the advanced tertiary care centers equipped with the best scanners and best interpreters. Considering that …

Letter by Yeo et al Regarding Article, “Time-Dependent Test Characteristics of Head CT in Patients Suspected of Nontraumatic Subarachnoid Hemorrhage”