Endoglin Deficiency in Bone Marrow is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse After Vascular Endothelial Growth Factor Stimulation | Zendy

EunJung Choi | Zendy; Espen J. Walker | Zendy; Vincent Degos | Zendy; Kristine Jun | Zendy; Robert Kuo | Zendy; John PileSpellman | Zendy; Hua Su | Zendy; William L. Young | Zendy

Open Access

Endoglin Deficiency in Bone Marrow is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse After Vascular Endothelial Growth Factor Stimulation

Author(s) -

EunJung Choi,

Espen J. Walker,

Vincent Degos,

Kristine Jun,

Robert Kuo,

John PileSpellman,

Hua Su,

William L. Young

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.671974

Subject(s) - medicine , endoglin , stimulation , dysplasia , bone marrow , vascular endothelial growth factor , growth factor , vascular disease , pathology , endocrinology , vegf receptors , stem cell , genetics , receptor , cd34 , biology

Bone marrow-derived cells (BMDCs) home to vascular endothelial growth factor (VEGF)-induced brain angiogenic foci, and VEGF induces cerebrovascular dysplasia in adult endoglin heterozygous (Eng(+/-)) mice. We hypothesized that Eng(+/-) BMDCs cause cerebrovascular dysplasia in the adult mouse after VEGF stimulation.

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