High-density Lipoprotein–based Therapy Reduces the Hemorrhagic Complications Associated With Tissue Plasminogen Activator Treatment in Experimental Stroke | Zendy

Bertrand Lapergue | Zendy; Bao Quoc Dang | Zendy; JeanPhilippe Désilles | Zendy; Guadalupe Ortiz-Muñoz | Zendy; Sandrine Delbosc | Zendy; Stéphane Loyau | Zendy; Liliane Louedec | Zendy; PierreOlivier Couraud | Zendy; Mikaël Mazighi | Zendy; JeanBaptiste Michel | Zendy; Olivier Meilhac | Zendy; Pierre Amarenco | Zendy

Open Access

High-density Lipoprotein–based Therapy Reduces the Hemorrhagic Complications Associated With Tissue Plasminogen Activator Treatment in Experimental Stroke

Author(s) -

Bertrand Lapergue,

Bao Quoc Dang,

JeanPhilippe Désilles,

Guadalupe Ortiz-Muñoz,

Sandrine Delbosc,

Stéphane Loyau,

Liliane Louedec,

PierreOlivier Couraud,

Mikaël Mazighi,

JeanBaptiste Michel,

Olivier Meilhac,

Pierre Amarenco

Publication year - 2013

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.667832

Subject(s) - medicine , tissue plasminogen activator , stroke (engine) , in vivo , blood–brain barrier , plasminogen activator , neuroprotection , pharmacology , anesthesia , central nervous system , mechanical engineering , microbiology and biotechnology , engineering , biology

We have previously reported that intravenous injection of high-density lipoproteins (HDLs) was neuroprotective in an embolic stroke model. We hypothesized that HDL vasculoprotective actions on the blood-brain barrier (BBB) may decrease hemorrhagic transformation-associated with tissue plasminogen activator (tPA) administration in acute stroke.

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