Endothelin Receptor Antagonists for Aneurysmal Subarachnoid Hemorrhage | Zendy

Mervyn D.I. Vergouwen | Zendy; Ale Algra | Zendy; Gabriël J.E. Rinkel | Zendy

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Endothelin Receptor Antagonists for Aneurysmal Subarachnoid Hemorrhage

Author(s) -

Mervyn D.I. Vergouwen,

Ale Algra,

Gabriël J.E. Rinkel

Publication year - 2012

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.112.666693

Subject(s) - medicine , subarachnoid hemorrhage , endothelin receptor antagonist , vasospasm , relative risk , cerebral vasospasm , endothelin receptor , bosentan , stroke (engine) , placebo , meta analysis , anesthesia , confidence interval , pathology , receptor , mechanical engineering , alternative medicine , engineering

Endothelin is considered to be a key mediator of vasospasm after subarachnoid hemorrhage. A meta-analysis of randomized trials on the effectiveness of endothelin receptor antagonists in subarachnoid hemorrhage has been published previously, but since then new major trials have been published. We present the results of a systematic review and meta-analysis update.

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